It happened on Holloway Street and Brye Street around 9:40 a.m.
Officers upon arrival found a man who was shot. Durham police said he was pronounced dead at the scene.
Holloway Street will be closed for several hours between Raynor Street and Guthrie Street due to the ongoing investigation.
There is no word on any suspects or the circumstances surrounding the incident. ABC11 is working to learn more.
This comes after an overnight shooting in Durham on Lednum Street and Leon Street.