The TV and radio presenter, who competed in the 14th season of Strictly with Joanne Clifton, tied the knot with Portia in 2015.
Sharing the sad news on his Instagram page, Ore wrote: "Hi guys. Portia and I are sad to announce that we separated earlier this year.
"We're so grateful for all the love you've shared with us both over the years.
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"And we want to thank you in advance for respecting our privacy as we navigated this difficult transition.
"We will be making no further comment. Be kind, always."
The former couple began dating in 2010 while studying at Loughborough University, with Ore proposing four years later.
Ore and Portia wed in 2015 at Penshurst Place in Kent, with the TV star telling The Mirror at the time: "On my wedding day, I cried from 11 in the morning until 2am that night.
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"There's a picture of me wailing, my best men there laughing and Portia absolutely cracking up next to me - I am the only one crying."
They share two children, son Roman born in 2018 and daughter Genie who followed in 2021.
Opening up about how parenthood changed the dynamic of their relationship, Ore said on Good Morning Britain in 2021: "My wife and I will be ten years together next month, and we've never done anything more challenging than the last 12 months. There were tears, tantrums.
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"Roman has enhanced our world more than we could have dreamt, but there are times we have to remember that we love each other and that's why he's here. He's been our guardian angel in lockdown but he's also been the cause of a few little tiffs."
He added: "It's just finding that time for each other. Every household is different. Communication is the key. We don't go to bed in an argument."