England lock George Martin has been ruled out of Saturday's Guinness Six Nations showdown against Scotland.
The 23-year-old Leicester player, who was due to be on Steve Borthwick's bench for the Calcutta Cup clash, has been replaced by Bath forward Ted Hill.
Martin started England's 26-25 round-two win over France but has been managing a knee problem.
Ollie Chessum took Martin's place in the second row alongside captain Maro Itoje when head coach Borthwick named his team on Tuesday.
England attack coach Richard Wigglesworth said: "Unfortunately, George Martin had a bit of a setback this morning, so he's been withdrawn from the 23 and Ted Hill comes on to the bench in his place.
"He had a couple of bangs post the France game that he and we thought were going to be all right.
"But to go and play a Test match, you have to be close to a hundred per cent.
"He's not quite right this morning so we made that decision pre-training. Ted Hill trained fully in that position."